Along came a spider: AID escapes a microRNA web
- PMID: 18482561
- DOI: 10.1016/j.immuni.2008.04.012
Along came a spider: AID escapes a microRNA web
Abstract
In this issue of Immunity, Teng et al. (2008) and Dorsett et al. (2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is associated with defective affinity maturation and increased Myc-Igh translocations.
Comment on
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MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.Immunity. 2008 May;28(5):621-9. doi: 10.1016/j.immuni.2008.03.015. Epub 2008 May 1. Immunity. 2008. PMID: 18450484 Free PMC article.
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MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.Immunity. 2008 May;28(5):630-8. doi: 10.1016/j.immuni.2008.04.002. Epub 2008 May 1. Immunity. 2008. PMID: 18455451 Free PMC article.
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