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Comment

. 2008 Jun 1;63(11):1005-6.

doi: 10.1016/j.biopsych.2008.03.016.

Brain norepinephrine rediscovered in addiction research

Gary Aston-Jones¹, Peter W Kalivas

Affiliations

PMID: 18482610
PMCID: PMC2666333
DOI: 10.1016/j.biopsych.2008.03.016

Comment

Brain norepinephrine rediscovered in addiction research

Gary Aston-Jones et al. Biol Psychiatry. 2008.

. 2008 Jun 1;63(11):1005-6.

doi: 10.1016/j.biopsych.2008.03.016.

Authors

Gary Aston-Jones¹, Peter W Kalivas

Affiliation

¹ Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. astrong@musc.edu

PMID: 18482610
PMCID: PMC2666333
DOI: 10.1016/j.biopsych.2008.03.016

No abstract available

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Figures

Figure 1
Schematic illustrating NE projections to the BNST in rat brain, and subsequent outputs from the BNST to other regions of the limbic system. In the case of opioid withdrawal, activation of NE neurons in the NTS and A1 cell groups enhance NE release in the BNST. NE acting at β-NE receptors in the BNST activates neurons projecting to various limbic regions, such as the nucleus accumbens (NAcc), amygdala, periaqueductal gray (PAG), hypothalamus, and perhaps other regions. Adapted from Aston-Jones et al (1999).

See this image and copyright information in PMC

Comment on

Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety.
Schank JR, Liles LC, Weinshenker D. Schank JR, et al. Biol Psychiatry. 2008 Jun 1;63(11):1007-12. doi: 10.1016/j.biopsych.2007.10.018. Epub 2008 Feb 20. Biol Psychiatry. 2008. PMID: 18083142 Free PMC article.
Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies.
Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ. Zachariou V, et al. Biol Psychiatry. 2008 Jun 1;63(11):1013-21. doi: 10.1016/j.biopsych.2007.11.021. Epub 2008 Jan 28. Biol Psychiatry. 2008. PMID: 18222416 Free PMC article.

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