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Comment
. 2008 May;15(5):415-6.
doi: 10.1016/j.chembiol.2008.04.009.

Pinning down the polo-box domain

Kyung S Lee  1 , Jeffrey R Idle
Affiliations
Comment

Pinning down the polo-box domain

Kyung S Lee et al. Chem Biol. 2008 May.

Abstract

Polo-like kinase 1 (Plk1) appears to be an attractive target for anticancer therapy. In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with the function of the polo-box domain (PBD) of Plk1.

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