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Comment
. 2008 Jun;9(6):521-2.
doi: 10.1038/embor.2008.84. Epub 2008 May 16.

A new regulatory loop in cancer-cell invasion

Oscar H Ocaña  1 , M Angela Nieto
Affiliations
Comment

A new regulatory loop in cancer-cell invasion

Oscar H Ocaña et al. EMBO Rep. 2008 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of the regulatory loop between the miR-200 family and ZEB factors. (A) Various cellular states are characterized by the relative activity of Zeb genes and members of the miR-200 family. The epithelial cell expresses high levels of miR-200 and E-cadherin, whereas the mesenchymal cell expresses high levels of ZEB and vimentin. Active genes are shown in black and inactive genes in grey (adapted from Gregory et al, 2008; Park et al, 2008 and Burk et al, 2008). (B) The two cellular states can be two outcomes of a circuit in which a signal (in this case S = TGFβ) induces the expression of transcription factors (in this case TF = ZEB factors). These transcription factors are the targets of the microRNAs (miRNAs) that they repress (in this case the miR-200 family), generating a negative-feedback loop (see Tsang et al, 2007 for coordinated transcriptional and miRNA-mediated regulatory models). The miRNA negatively regulates not only the expression of the TFs but also the expression of the signal (TGFβ). EMT, epithelial-to-mesenchymal transition; MET, mesenchymal-to-epithelial transition; SIP1, Smad interacting protein 1; TGFβ, transforming growth factor-β; ZEB, zinc-finger E-box-binding homeobox transcription factors.
None
See this image and copyright information in PMC

Comment on

References

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