Difference in tissue expression of tumour markers CA 19-9 and CA 50 in hepatocellular carcinoma and cholangiocarcinoma
- PMID: 1848439
- PMCID: PMC1971873
- DOI: 10.1038/bjc.1991.90
Difference in tissue expression of tumour markers CA 19-9 and CA 50 in hepatocellular carcinoma and cholangiocarcinoma
Abstract
The expression of tumour markers CA 19-9 and CA 50, defined by the monoclonal antibodies 1116 NS 19-9 (19-9 antibody) and C 50, was studied by the immunoperoxidase technique in formalin-fixed, paraffin-embedded tissue sections from 11 hepatocellular carcinomas and 10 cholangiocarcinomas of the liver, and from specimens of normal liver and liver cirrhosis. The 19-9 and C 50 antibodies react with sialosylfucosyllactotetraose, corresponding to sialylated blood group antigen Lewis, and the C 50 antibody also with another sugar moiety, sialosyllactotetraose. Neither marker was cancer specific. The CA 19-9 and CA 50 antigens are normal constituents of bile ducts. Nine out of 10 cholangiocarcinomas stained for CA 50, and eight out of 10 for CA 19-9. There was no apparent difference between the staining pattern of CA 19-9 and CA 50. Hepatocellular carcinomas were consistently negative for both markers. Thus, hepatocellular carcinomas and cholangiocarcinomas showed a clear difference in the reactivity for tumour marker antigens CA 19-9 and CA 50. This difference might be of clinical importance in the differential diagnosis between hepatocellular carcinoma and cholangiocarcinoma.
Similar articles
-
Expression of ABH and Lewis blood group antigens in combined hepatocellular-cholangiocarcinoma. Possible evidence for the hepatocellular origin of combined hepatocellular-cholangiocarcinoma.Cancer. 1987 Aug 1;60(3):345-52. doi: 10.1002/1097-0142(19870801)60:3<345::aid-cncr2820600311>3.0.co;2-t. Cancer. 1987. PMID: 3036328
-
Blood-group-related antigen Lewis(x) and Lewis(y) in the differential diagnosis of cholangiocarcinoma and hepatocellular carcinoma.Arch Pathol Lab Med. 1989 Feb;113(2):139-42. Arch Pathol Lab Med. 1989. PMID: 2537068
-
Expression of Lewis blood group antigens in cancerous and non-cancerous liver.Jpn J Cancer Res. 1987 Sep;78(9):968-76. Jpn J Cancer Res. 1987. PMID: 2822639
-
Tissue expression of the tumor marker CA 50 in benign and malignant pancreatic lesions. A comparison with CA 19-9.Int J Cancer. 1986 Dec 15;38(6):841-6. doi: 10.1002/ijc.2910380610. Int J Cancer. 1986. PMID: 3466871
-
Cytokines and liver disease.Jpn J Med. 1991 Nov-Dec;30(6):606-9. doi: 10.2169/internalmedicine1962.30.606. Jpn J Med. 1991. PMID: 1665880 Review. No abstract available.
Cited by
-
The stem cells of the liver--a selective review.J Cancer Res Clin Oncol. 1992;118(2):87-115. doi: 10.1007/BF01187498. J Cancer Res Clin Oncol. 1992. PMID: 1346535 Free PMC article.
-
Circulating blood group related carbohydrate antigens as tumour markers.Glycoconj J. 1995 Jun;12(3):200-5. doi: 10.1007/BF00731320. Glycoconj J. 1995. PMID: 7496132 Review.
-
Serum increase and liver overexpression of carbohydrate 19.9 antigen in patients with genetic haemochromatosis.Gut. 1994 Aug;35(8):1107-11. doi: 10.1136/gut.35.8.1107. Gut. 1994. PMID: 7926915 Free PMC article.
-
Carbohydrate Antigen 50: Values for Diagnosis and Prognostic Prediction of Intrahepatic Cholangiocarcinoma.Medicina (Kaunas). 2020 Nov 16;56(11):616. doi: 10.3390/medicina56110616. Medicina (Kaunas). 2020. PMID: 33207685 Free PMC article.
-
MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report.Oncol Lett. 2017 Mar;13(3):1655-1659. doi: 10.3892/ol.2017.5643. Epub 2017 Jan 25. Oncol Lett. 2017. PMID: 28454305 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous