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. 1991 Mar 21;350(6315):207-11.
doi: 10.1038/350207a0.

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus

H Acha-Orbea  1 , A N Shakhov, L Scarpellino, E Kolb, V Müller, A Vessaz-Shaw, R Fuchs, K Blöchlinger, P Rollini, J Billotte, et al.
Affiliations

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus

H Acha-Orbea et al. Nature. .

Abstract

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.

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