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Review
. 2008 Jul;17(3):485-502, vii-viii.
doi: 10.1016/j.soc.2008.02.007.

Multidisciplinary treatment of advanced cancer of the esophagus and gastroesophageal junction: a European center's approach

Toni Lerut  1 , Johnny Moons, Willy Coosemans, Herbert Decaluwé, Georges Decker, Paul De Leyn, Philippe Nafteux, Dirk Van Raemdonck
Affiliations
Review

Multidisciplinary treatment of advanced cancer of the esophagus and gastroesophageal junction: a European center's approach

Toni Lerut et al. Surg Oncol Clin N Am. 2008 Jul.

Abstract

Tremendous progress has been made in surgery for cancer of the esophagus and gastroesophageal junction. After primary surgery, overall 5-year survival rates of 35% or more are obtained in high-volume units, and for advanced stage III cancer, 5-year survival reaches 25%. Multimodality therapy, in particular induction chemotherapy with or without radiotherapy, results in a complete response rate in up to 25% of the patients. Approximately 50% of the patients receiving such treatment do not respond, however, and their outcome is dismal. Therefore, further efforts are needed to elaborate more precise algorithms for selecting candidates for induction therapy versus primary surgery.

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