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. 2008 Aug;31(8):1668-9.
doi: 10.2337/dc08-0706. Epub 2008 May 16.

Increased risk of cardiovascular disease in young women following gestational diabetes mellitus

Baiju R Shah  1 , Ravi Retnakaran, Gillian L Booth
Affiliations

Increased risk of cardiovascular disease in young women following gestational diabetes mellitus

Baiju R Shah et al. Diabetes Care. 2008 Aug.

Abstract

Objective: To determine whether women with gestational diabetes mellitus (GDM) have an increased risk of cardiovascular disease (CVD) following pregnancy.

Research design and methods: All women aged 20-49 years with live births between April 1994 and March 1997 in Ontario, Canada, were identified. Women with GDM were matched with 10 women without GDM and were followed for CVD.

Results: The matched cohorts included 8,191 women with GDM and 81,262 women without GDM. Mean age at entry was 31 years, and median follow-up was 11.5 years. The hazard ratio for CVD events was 1.71 (95% CI 1.08-2.69). After adjustment for subsequent type 2 diabetes, the hazard ratio was attenuated (1.13 [95% CI 0.67-1.89]).

Conclusions: Young women with GDM had a substantially increased risk for CVD compared with women without GDM. Much of this increased risk was attributable to subsequent development of type 2 diabetes.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves for CVD and CAD events and hazard ratios (HRs) derived from Cox proportional hazards regression.
See this image and copyright information in PMC

References

    1. King H: Epidemiology of glucose intolerance and gestational diabetes in women of childbearing age. Diabetes Care 21(Suppl. 2):B9–B13, 1998 - PubMed
    1. Kim C, Newton KM, Knopp RH: Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 25:1862–1868, 2002 - PubMed
    1. Verma A, Boney CM, Tucker R, Vohr BR: Insulin resistance syndrome in women with prior history of gestational diabetes mellitus. J Clin Endocrinol Metab 87:3227–3235, 2002 - PubMed
    1. Lauenborg J, Mathiesen E, Hansen T, Glumer C, Jorgensen T, Borch-Johnsen K, Hornnes P, Pedersen O, Damm P: The prevalence of the metabolic syndrome in a Danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. J Clin Endocrinol Metab 90:4004–4010, 2005 - PubMed
    1. Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, Kahn SE, the American Diabetes Association GENNID Study Group: Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care 29:2078–2083, 2006 - PubMed

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