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Multicenter Study
. 2008;26(4):347-53.
doi: 10.1159/000133430. Epub 2008 May 19.

Effect of high fiber density ratio polysulfone dialyzer on protein removal

Tadashi Tomo  1 , Makoto Matsuyama, Takeshi Nakata, Jun-Ichi Kadota, Shigeki Toma, Nobuhiko Koga, Hiroyoshi Fukui, Kenji Arizono, Tomi Takamiya, Kazuhiro Matsuyama, Satonori Ueyama, Yoshiki Shiohira, Yoshinao Uezu, Akira Higa
Affiliations
Multicenter Study

Effect of high fiber density ratio polysulfone dialyzer on protein removal

Tadashi Tomo et al. Blood Purif. 2008.

Abstract

Background/aims: A dialyzer (APS-EX) with a higher hollow fiber density ratio was manufactured using the highest performance polysulfone hollow fiber from Asahi-Kasei Medical.

Methods: We compared the performance of this device in comparison with hemodialysis (HD; APS-S) and hemodiafiltration (HDF) conditions (APS-S, 10 l post-HDF) to evaluate its merit as an internal filtration-enhanced dialyzer.

Results: With low molecular weight proteins, APS-EX had a reduction ratio of 74.3% for beta(2)-microglobulin (beta(2)-MG), and 31.0% for alpha(1)-MG. APS-EX had a significant higher removal amount of alpha(1)-MG compared to APS-S (HDF). Significant differences were seen in albumin loss, 4.0 g for APS-EX, 3.0 g for APS-S (HDF), and 0.9 g for APS-S (HD). Using HD mode, APS-EX demonstrated a performance which was more than equivalent to approximately 10 l post-HDF.

Conclusions: The results suggested the possibility that HD equivalent to HDF can be performed safely with the ultrapure dialysate when using APS-EX with internal filtration.

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