Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jul;40(7):838-40.
doi: 10.1038/ng.163. Epub 2008 May 18.

Common sequence variants on 20q11.22 confer melanoma susceptibility

Kevin M Brown  1 , Stuart Macgregor, Grant W Montgomery, David W Craig, Zhen Zhen Zhao, Kelly Iyadurai, Anjali K Henders, Nils Homer, Megan J Campbell, Mitchell Stark, Shane Thomas, Helen Schmid, Elizabeth A Holland, Elizabeth M Gillanders, David L Duffy, Judith A Maskiell, Jodie Jetann, Megan Ferguson, Dietrich A Stephan, Anne E Cust, David Whiteman, Adele Green, Håkan Olsson, Susana Puig, Paola Ghiorzo, Johan Hansson, Florence Demenais, Alisa M Goldstein, Nelleke A Gruis, David E Elder, Julia Newton Bishop, Richard F Kefford, Graham G Giles, Bruce K Armstrong, Joanne F Aitken, John L Hopper, Nicholas G Martin, Jeffrey M Trent, Graham J Mann, Nicholas K Hayward
Affiliations

Common sequence variants on 20q11.22 confer melanoma susceptibility

Kevin M Brown et al. Nat Genet. 2008 Jul.

Abstract

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Association analysis of SNPs across a region of chromosome 20q11.22. P-values for association testing for the three samples a, Q1; b, Q2; c, A1 are shown.
Figure 2
Figure 2
Association analysis of SNPs across a region of chromosome 20q11.22 for the combined sample. Genes from AHCY to PROCP are shown in black; two candidate genes, E2F1 and ASIP, are shown in grey.
See this image and copyright information in PMC

Comment in

  • Shedding light on skin cancer.
    Pharoah PD. Pharoah PD. Nat Genet. 2008 Jul;40(7):817-8. doi: 10.1038/ng0708-817. Nat Genet. 2008. PMID: 18583973 No abstract available.

References

    1. Lens MB, Dawes M. Br. J. Dermatol. 2004;150:179–185. - PubMed
    1. de Snoo FA, Hayward NK. Cancer Lett. 2005;230:153–186. - PubMed
    1. Palmer JS, et al. Am. J. Hum. Genet. 2000;66:176–186. - PMC - PubMed
    1. Landi MT, et al. J. Natl. Cancer Inst. 2005;97:998–1007. - PubMed
    1. Baxter A, et al. Twin Res. Hum. Genet. 2008;11:183–96. - PMC - PubMed

Publication types