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Review
. 2008 Oct;57(10):1523-9.
doi: 10.1007/s00262-008-0531-4. Epub 2008 May 17.

Combined modality immunotherapy and chemotherapy: a new perspective

Rupal Ramakrishnan  1 , Scott Antonia, Dmitry I Gabrilovich
Affiliations
Review

Combined modality immunotherapy and chemotherapy: a new perspective

Rupal Ramakrishnan et al. Cancer Immunol Immunother. 2008 Oct.

Abstract

The results of recent clinical trials have demonstrated that cancer vaccines continue to struggle to achieve tangible clinical benefits as monotherapy. Tumor-induced abnormalities in the immune system hamper anti-tumor T cell responses limiting the effectiveness of cancer immunotherapy. Recently, evidence has been mounting to suggest that immunotherapy has the possibility of achieving better success when used in combination with conventional chemotherapy. In clinical trials, immune responses elicited by cancer vaccines appear to augment the effectiveness of subsequent conventional cancer therapies.

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