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Review
. 2008;3(1):21-9.

Tumor targeting using liposomal antineoplastic drugs

Jörg Huwyler  1 , Jürgen Drewe, Stephan Krähenbuhl
Affiliations
Review

Tumor targeting using liposomal antineoplastic drugs

Jörg Huwyler et al. Int J Nanomedicine. 2008.

Abstract

During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.

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