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Comparative Study
. 2008;3(1):125-32.

The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement

Alyssa Ricker  1 , Peishan Liu-Snyder, Thomas J Webster
Affiliations
Comparative Study

The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement

Alyssa Ricker et al. Int J Nanomedicine. 2008.

Abstract

A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO4 reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO4 compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO4 should be further studied for improving properties of PMMA for orthopedic applications.

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Figures

Figure 1
Figure 1
SEM images of PMMA with nano BaSO4 or nano MgO.
Figure 2
Figure 2
Increased osteoblast adhesion on PMMA with either nano MgO or conventional/nano BaSO4. Data = mean ± SEM; n = 3; Δ p < 0.1 (compared to PMMA alone and PMMA with conventional MgO); *p < 0.01 (compared to PMMA with conventional MgO).
Figure 3
Figure 3
Increased osteoblast adhesion on PMMA with either nano MgO or conventional/nano BaSO4 (mag. = 100X).
See this image and copyright information in PMC

References

    1. Barralet JE, Lilley KJ, Grover LM, et al. Cements from nanocrystalline hydroxyapatite. J Mater Sci Mater Med. 2004;15:407. - PubMed
    1. Bhambri SK, Gilbertson LN. Micromechanisms of fatigue crack initiation and propagation in bone cements. J Biomed Mater Res. 1995;29:233–7. - PubMed
    1. Biehl G, Harms J, Hanser U. Experimentelle untersuchungen über die wärmeentwicklung im knochen bei der polymerisation von knochenzement. Arch Orthop Unfallchir. 1974;78:62. - PubMed
    1. Gauthier O, Bouler JM, Weiss P, et al. Kinetic study of bone ingrowth and ceramic resorption associated with the implantation of different injectable calcium-phosphate bone substitutes. J Biomed Mater Res. 1999;47:28. - PubMed
    1. Gbureck U, Barralet JE, Hofmann MP, et al. Nanocrystalline tetracalcium phosphate cement. J Dent Res. 2004;83:425. - PubMed

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