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. 2008 Mar-Apr;71(2):50-2.

[Afobazole metabolism in rats]

[Article in Russian]
S B Seredenin, A O Viglinskaia, T Ia Mozhaeva, G B Kolyvanov, A A Litvin, N I Avdiunina, V L Savel'ev, V P Zgerdev
  • PMID: 18488909

[Afobazole metabolism in rats]

[Article in Russian]
S B Seredenin et al. Eksp Klin Farmakol. 2008 Mar-Apr.

Abstract

Metabolism of afobazole in rats has been studied using mass-spectrometry and HPLC, which revealed 17 products of afobazole biotransformation along with the parent compound. The structures of six afobazole metabolites were established and confirmed by comparison of HPLC retention times with the synthetic reference compounds and HPLC/mass spectrometry. Other metabolites were characterized by the masses of molecular ions. A significant fraction of the drug dose is biotransformed with the formation of hydroxylated benzimidazole moiety and oxidated morpholine.

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