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. 1991 Apr;163(4):716-9.
doi: 10.1093/infdis/163.4.716.

Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection

W L Drew  1 , R C Miner, D F Busch, S E Follansbee, J Gullett, S G Mehalko, S M Gordon, W F Owen Jr, T R Matthews, W C Buhles, et al.
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Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection

W L Drew et al. J Infect Dis. 1991 Apr.

Abstract

Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the development of drug-resistant virus. No resistant strains were found in 31 patients before therapy or among seven culture-positive patients treated for less than or equal to 3 months. Of 13 culture-positive patients treated for greater than or equal to 3 months, 5 excreted virus resistant (ED50, greater than 12 microM, or ED90, greater than 30 microM) to ganciclovir. Thus, 38% of patients and receiving ganciclovir for greater than 3 months and excreting virus or, overall, 7.6% of the patients were excreting CMV resistant to the drug.

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