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. 2008 Jun 19;10(12):2381-4.
doi: 10.1021/ol8006277. Epub 2008 May 21.

Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles

Natsuko Kagawa  1 , Jeremiah P Malerich, Viresh H Rawal
Affiliations

Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles

Natsuko Kagawa et al. Org Lett. .

Abstract

Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.

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Figures

Scheme 1
Scheme 1
Scheme 2
Scheme 2
Allylation of complex natural products
See this image and copyright information in PMC

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