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. 1991 Feb 27;101(1):67-71.
doi: 10.1007/BF00238439.

Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle

M A Perales  1 , A Sener, W J Malaisse
Affiliations

Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle

M A Perales et al. Mol Cell Biochem. .

Abstract

Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when expressed relative to the protein content, less than 2% of the value recorded in liver microsomes. Moreover, no phosphotransferase activity was detected in the islets. These findings impose reservation on both the presence of glucose-6-phosphatase in rat islets and its participation to stimulus-secretion coupling.

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