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. 1991 Jan 11;19(1):53-8.
doi: 10.1093/nar/19.1.53.

Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules

M Graessmann  1 , G Michaels, B Berg, A Graessmann
Affiliations
Free PMC article

Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules

M Graessmann et al. Nucleic Acids Res. .
Free PMC article

Abstract

We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis.

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