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Comment
. 2008 May 27;105(21):7343-4.
doi: 10.1073/pnas.0804122105. Epub 2008 May 20.

Rhodopsin's active state is frozen like a DEER in the headlights

Thomas Huber  1 , Thomas P Sakmar
Affiliations
Comment

Rhodopsin's active state is frozen like a DEER in the headlights

Thomas Huber et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Dynamic receptors. Rhodopsin is depicted in a phospholipid bilayer membrane. The structure was simulated in a model bilayer environment (15-ns and 45,000 atoms) starting from the crystal structure (1HZX) (19). The retinylidene ligand is shown in red; the lipid acyl carbonyl carbons representing the hydrophobic boundary are shown as white balls; and the phosphates representing the headgroups are in orange. The extracellular surface is toward the top and the cytoplasmic surface toward the bottom. DEER shows that the cytoplasmic end of TM6 moves away from the center of the receptor upon activation, which likely requires rigid-body movement of the helix.
See this image and copyright information in PMC

Comment on

References

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