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Review
. 2008 Jul;4(7):382-93.
doi: 10.1038/ncpendmet0843. Epub 2008 May 20.

The prevention of type 2 diabetes

Jill P Crandall  1 , William C Knowler, Steven E Kahn, David Marrero, Jose C Florez, George A Bray, Steven M Haffner, Mary Hoskin, David M Nathan; Diabetes Prevention Program Research Group
Affiliations
Review

The prevention of type 2 diabetes

Jill P Crandall et al. Nat Clin Pract Endocrinol Metab. 2008 Jul.

Abstract

Type 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action--potential targets of preventive interventions--are impaired. In trials lifestyle modification (i.e. weight loss and exercise) has proven effective in preventing incident T2DM in high-risk groups, although weight loss has the greatest effect. Various medications (e.g. metformin, thiazolidinediones and acarbose) can also prevent or delay T2DM. Whether diabetes-prevention strategies also ultimately prevent the development of diabetic vascular complications is unknown, but cardiovascular risk factors are favorably affected. Preventive strategies that can be implemented in routine clinical settings have been developed and evaluated. Widespread application has, however, been limited by local financial considerations, even though cost-effectiveness might be achieved at the population level.

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References

    1. Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2005. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2005.
    1. Jensen CC, et al. Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US. Diabetes. 2002;51:2170–2178. - PubMed
    1. Weyer C, et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104:787–794. - PMC - PubMed
    1. Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia. 2003;46:3–19. - PubMed
    1. Jarrett RJ, et al. Worsening to diabetes in men with impaired glucose tolerance (“borderline diabetes”) Diabetologia. 1979;16:25–30. - PubMed

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