Is infliximab safe to use while breastfeeding?
- PMID: 18494064
- PMCID: PMC2712180
- DOI: 10.3748/wjg.14.3085
Is infliximab safe to use while breastfeeding?
Abstract
Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.
References
-
- Jospe ES, Peppercorn MA. Inflammatory bowel disease and pregnancy: a review. Dig Dis. 1999;17:201–207. - PubMed
-
- Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006;4:1255–1258. - PubMed
-
- Srinivasan R. Infliximab treatment and pregnancy outcome in active Crohn's disease. Am J Gastroenterol. 2001;96:2274–2275. - PubMed
-
- Remicade product information. In: Physicians desk reference. 58th ed. Montvale, NJ: Medical Economics Company, Inc; 2004. pp. 1145–1148.
-
- Reddy JG, Loftus EV Jr. Safety of infliximab and other biologic agents in the inflammatory bowel diseases. Gastroenterol Clin North Am. 2006;35:837–855. - PubMed
