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Case Reports
. 2008 May 21;14(19):3101-4.
doi: 10.3748/wjg.14.3101.

Primary lymphoblastic B-cell lymphoma of the stomach: a case report

Affiliations
Case Reports

Primary lymphoblastic B-cell lymphoma of the stomach: a case report

Miao-Xia He et al. World J Gastroenterol. .

Abstract

Primary stomach lymphoblastic B-cell lymphoma (B-LBL) is a rare tumor. We describe a primary stomach B-LBL in a 38 years old female who presented with nonspecific complaints of fatigue and vomiting for 2 mo. Gastrofiberscopy revealed a large gastric ulcer, which was successfully resected. Pathology showed a lymphoblastic cell lymphoma arising from the stomach, and there was no evidence of disease at any extrastomach site. Immunohistochemical staining and gene rearrangement studies supported that the stomach tumor was a clonal B-cell lymphoma. Therefore, the diagnosis of B-LBL was made based on the stomach specimen.

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Figures

Figure 1
Figure 1
A large neoplastic ulcer in the stomach involving the whole gastric wall.
Figure 2
Figure 2
Diffuse proliferation of lymphoblastic cells between gastric glands of stomach B-LBL. A: HE, × 100; B: HE, × 200; C: HE, × 200; D: Tumor emboli within lymphatic vessels of the gastric wall (HE, × 100).
Figure 3
Figure 3
Stomach B-LBL (EnVision, × 200). A: Lym-phoblasts diffusely stained with anti-CD79a; B: A large number of lymphoblasts positive for nuclear antigen TdT; C: Lymphoblasts diffusely stained with anti-CD10; D: A large number of lymphoblasts positive for Ki-67.
Figure 4
Figure 4
Polymerase chain reaction showing rearrangement of immunoglobulin heavy-chain genes. Lane 1: Marker; lane 2: FR2, sample collected from stomach B cell lymphoblastic lymphoma showing monoclonal pattern; lane 3: FR3A, sample collected from stomach B cell lymphoblastic lymphoma showing a smear; lane 4: FR2, B cell lymphoma cell line Raja used as positive control; lane 5, FR3A, B cell lymphoma cell line Raja used as positive control. Lane 6, JVI, sample collected from stomach B cell lymphoblastic lymphoma showing a negative pattern; lane 7: JVII, sample collected from stomach B cell lymphoblastic lymphoma showing a negative pattern; lane 8: JVI, T cell lymphoma cell line Jurkat used as a positive control; lane 9: JVII, T cell lymphoma cell line Jurkat used as a positive control.

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References

    1. Precursor B lymphoblastic leukemia/lymphoblastic lymphoma. Lyon, France: IARC Press; 2001. In: Jaffe ES, Harris NL, Stein H, Stein H, Vardiman JW. World Health Organization classification of tumour, Pathology and genetics of tumours of haematopoietic and lymphoid tissues. International agency for reseach on cancer; pp. 109–117.
    1. Soslow RA, Baergen RN, Warnke RA. B-lineage lymphoblastic lymphoma is a clinicopathologic entity distinct from other histologically similar aggressive lymphomas with blastic morphology. Cancer. 1999;85:2648–2654. - PubMed
    1. Lin P, Jones D, Dorfman DM, Medeiros LJ. Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement. Am J Surg Pathol. 2000;24:1480–1490. - PubMed
    1. Maitra A, McKenna RW, Weinberg AG, Schneider NR, Kroft SH. Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature. Am J Clin Pathol. 2001;115:868–875. - PubMed
    1. Burkhardt B, Zimmermann M, Oschlies I, Niggli F, Mann G, Parwaresch R, Riehm H, Schrappe M, Reiter A. The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol. 2005;131:39–49. - PubMed

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