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Case Reports
. 2008 May 21;14(19):3101-4.
doi: 10.3748/wjg.14.3101.

Primary lymphoblastic B-cell lymphoma of the stomach: a case report

Miao-Xia He  1 , Ming-Hua Zhu, Wei-Qiang Liu, Li-Li Wu, Xiong-Zeng Zhu
Affiliations
Case Reports

Primary lymphoblastic B-cell lymphoma of the stomach: a case report

Miao-Xia He et al. World J Gastroenterol. .

Abstract

Primary stomach lymphoblastic B-cell lymphoma (B-LBL) is a rare tumor. We describe a primary stomach B-LBL in a 38 years old female who presented with nonspecific complaints of fatigue and vomiting for 2 mo. Gastrofiberscopy revealed a large gastric ulcer, which was successfully resected. Pathology showed a lymphoblastic cell lymphoma arising from the stomach, and there was no evidence of disease at any extrastomach site. Immunohistochemical staining and gene rearrangement studies supported that the stomach tumor was a clonal B-cell lymphoma. Therefore, the diagnosis of B-LBL was made based on the stomach specimen.

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Figures

Figure 1
Figure 1
A large neoplastic ulcer in the stomach involving the whole gastric wall.
Figure 2
Figure 2
Diffuse proliferation of lymphoblastic cells between gastric glands of stomach B-LBL. A: HE, × 100; B: HE, × 200; C: HE, × 200; D: Tumor emboli within lymphatic vessels of the gastric wall (HE, × 100).
Figure 3
Figure 3
Stomach B-LBL (EnVision, × 200). A: Lym-phoblasts diffusely stained with anti-CD79a; B: A large number of lymphoblasts positive for nuclear antigen TdT; C: Lymphoblasts diffusely stained with anti-CD10; D: A large number of lymphoblasts positive for Ki-67.
Figure 4
Figure 4
Polymerase chain reaction showing rearrangement of immunoglobulin heavy-chain genes. Lane 1: Marker; lane 2: FR2, sample collected from stomach B cell lymphoblastic lymphoma showing monoclonal pattern; lane 3: FR3A, sample collected from stomach B cell lymphoblastic lymphoma showing a smear; lane 4: FR2, B cell lymphoma cell line Raja used as positive control; lane 5, FR3A, B cell lymphoma cell line Raja used as positive control. Lane 6, JVI, sample collected from stomach B cell lymphoblastic lymphoma showing a negative pattern; lane 7: JVII, sample collected from stomach B cell lymphoblastic lymphoma showing a negative pattern; lane 8: JVI, T cell lymphoma cell line Jurkat used as a positive control; lane 9: JVII, T cell lymphoma cell line Jurkat used as a positive control.
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