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Randomized Controlled Trial
. 2008 Jul-Aug;43(4):456-9.
doi: 10.1093/alcalc/agn043. Epub 2008 May 21.

Valproate treatment of acute alcohol hallucinosis: a double-blind, placebo-controlled study

Zafar N Aliyev  1 , Nadir A Aliyev
Affiliations
Randomized Controlled Trial

Valproate treatment of acute alcohol hallucinosis: a double-blind, placebo-controlled study

Zafar N Aliyev et al. Alcohol Alcohol. 2008 Jul-Aug.

Abstract

Aims: The aim of this study was to compare the efficacy and safety of valproate (Depakine-Chrono) versus placebo for the treatment of acute alcohol hallucinosis.

Methods: 10 days' randomized, double-blind, parallel study was conducted; 40 patients with an ICD-10 diagnosis of acute alcohol hallucinosis were randomized to valproate (Depakine-Chrono) 3000 mg/day (n = 20) or placebo (n = 20). The primary efficacy measure was the Clinical Global Improvement (CGI) and the Positive and Negative Syndrome Scale (PANSS), subscale for hallucinosis.

Results: Valproate-treated patients demonstrated a greater improvement than placebo-treated patients in CGI (P < 0.001) and PANSS subscale for verbal hallucinosis (P < 0.001).

Conclusion: Valproate is effective in the treatment of acute hallucinosis and is generally well tolerated.

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