Case Reports
doi: 10.1007/s00296-008-0590-z.
Epub 2008 May 22.
A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab
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- PMID: 18496698
- DOI: 10.1007/s00296-008-0590-z
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Case Reports
A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab
Rheumatol Int.
2008 Sep.
Abstract
We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.
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