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. 2008 Aug;35(8):901-6.
doi: 10.1007/s10295-008-0363-4. Epub 2008 May 22.

Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans

Prashant P Deshpande  1 , Venkata B Nanduri, Annie Pullockaran, Hamish Christie, Richard H Mueller, Ramesh N Patel
Affiliations

Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans

Prashant P Deshpande et al. J Ind Microbiol Biotechnol. 2008 Aug.

Abstract

Microbial hydroxylation of o-bromophenylacetic acid provided 2-bromo-5-hydroxyphenylacetic acid. This enabled a route to the key intermediate 4-bromo-2,3-dihydrobenzofuran for synthesizing a melatonin receptor agonist and sodium hydrogen exchange compounds. Pd-mediated coupling reactions of 4-bromo-2,3-dihydrobenzofuran provided easy access to the 4-substituted-2,3-dihydrobenzofurans.

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