Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 May 23;320(5879):1012; author reply 1012.
doi: 10.1126/science.1152366.

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman  1 , Steven Lingard, David Gems, Linda Partridge, Dominic J Withers
Affiliations
Comment

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman et al. Science. .

Abstract

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources