Review
doi: 10.1039/b718357g.
Epub 2008 Apr 21.
The oxa-Michael reaction: from recent developments to applications in natural product synthesis
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- PMID: 18497934
- DOI: 10.1039/b718357g
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Review
The oxa-Michael reaction: from recent developments to applications in natural product synthesis
Chem Soc Rev.
2008 Jun.
Abstract
In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products.
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