Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 May;8(2):188-92.
doi: 10.17305/bjbms.2008.2980.

Correlation between hormonal and lipid status in women in menopause

Lejla Mesalić  1 , Emir Tupković, Sulejman Kendić, Devleta Balić
Affiliations

Correlation between hormonal and lipid status in women in menopause

Lejla Mesalić et al. Bosn J Basic Med Sci. 2008 May.

Abstract

It is widely accepted that menopause leads to changes in hormonal status, metabolism and lipid profile. The aim of this study was to analyze the influence of menopause on the concentrations of lipids, lipoproteins and, the influence of estradiol, progesterone, FSH, LH on lipid profile in menopausal women as well. The menopausal women had higher but non-significant (p>0,05) concentrations of total cholesterol, VLDL, LDL, and triglycerides than women with regular menstruation. The concentration of HDL was significantly lower in menopausal women than in women with regular menstruation (p<0,05). Also, the concentration of apolipoprotein B was significantly higher in menopausal women (p<0,05), but the concentrations of apolipoprotein and lipoprotein (a) were lower but without significance (p>0,05). Estrogen concentration has significant negative correlation with VLDL and triglycerides (p<0,05) and significant positive correlation with HDL (p<0,05) in menopausal women. Progesterone concentration has shown no correlation with concentrations of lipids and lipoproteins in menopause. We can conclude that menopause leads to changes in lipid profile by reducing HDL, and elevating apolipoprotein B levels, thus increasing the risk for cardiovascular disease. These changes were caused by reduction of estrogen concentrations in menopause.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Correlation between estrogen and Lp(a) concentration in women with regular menstruation
FIGURE 2
FIGURE 2
Correlation between estradiol and triglyceride concentration in women in menopause
FIGURE 3
FIGURE 3
Correlation between estradiol and VLDL concentration in women in menopause
FIGURE 4
FIGURE 4
Correlation between apolipoprotein B and estradiol in women in menopause
See this image and copyright information in PMC

References

    1. Carr M.C, Kim KH, Zambon A, Mitchell E.S, Woods N.F, Casazza C.P, Purnell J.Q, Hokanson J.E, Brunzell J.D, Schwarz R.S. Changes in LDL density across the menopausal transition. J. Invest. Med. 2000;48:245–250. - PubMed
    1. Lamarche B, Moorjani S, Cantin B, Dagenais G.R, Lupien P.J, Despers J.P. Association of HDL2 and HDL3 subfractions with ischemic heart disease in men. Prospective results from the Quebec cardiovascular study. Arterioscler. Thromb. Vasc. Biol. 1997;17:1098–1105. - PubMed
    1. Gower B.A, Naggy T.R, Goran M.I, Toth M.J, Poehlman E.T. Fat distribution and plasma lipid-lipoprotein concentrations in pre- and postmenopausal women. Int. J. Obes. Relat. Metab. Disord. 1998;22(7):605–611. - PubMed
    1. Van Beek A.P, de Rujiter-Heistek F.C, Jansen H, Erkelens D.W. Sex steroids and plasma lipoprotein levels in healthy women: importance of androgens in the estrogen-deficient state. Metabolism. 2004;53(2):187–192. - PubMed
    1. Onat A, Yazici M, Can G, Sniderman A. Evidence for a complex risk profile in obese postmenopausal Turkish women with hypertriglyceridemia and elevated apoliptoprotein B. Clin. Sci. (Lond) 2004;107(1):97–104. - PubMed