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Review
. 2008 Jul;99(7):1311-8.
doi: 10.1111/j.1349-7006.2008.00836.x. Epub 2008 May 21.

Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions

Brigette B Y Ma  1 , Edwin P Hui, Anthony T C Chan
Affiliations
Review

Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions

Brigette B Y Ma et al. Cancer Sci. 2008 Jul.

Abstract

Systemic therapy is an integral part of the management of non-keratinizing nasopharyngeal carcinoma (NPC). The purposes of this review are to provide the latest results and future directions of clinical and translational research for this disease, and to illustrate how some of these new therapies have improved the treatment outcome for patients with NPC. Particular attention will be paid to the clinical application of chemotherapy in the adjunctive treatment of locoregionally advanced NPC, novel targeted drugs, Epstein-Barr virus-targeted vaccine therapies, and the use of plasma Epstein-Barr virus DNA as a biomarker for selecting patients for adjunctive therapies.

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References

    1. Law CK, Mang O. Cancer incidence in Hong Kong. Med Bull 2007; 12: 18–21.
    1. Lee AW, Sze WM, Au JS et al . Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 2005; 61: 1107–16. - PubMed
    1. Hui EP, Leung SF, Au JS et al . Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group. Cancer 2004; 101: 300–6. - PubMed
    1. Baujat B, Bourhis J, Chan AT et al . Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta‐analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 2006; 64: 47–56. - PubMed
    1. Huncharek M, Kupelnick B. Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal carcinoma: results of a meta‐analysis of 1528 patients from six randomized trials. Am J Clin Oncol 2002; 25: 219–23. - PubMed

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