SERCA2a gene therapy for heart failure: ready for primetime?
- PMID: 18500238
- PMCID: PMC4854184
- DOI: 10.1038/mt.2008.89
SERCA2a gene therapy for heart failure: ready for primetime?
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Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats.Mol Ther. 2008 Jun;16(6):1026-32. doi: 10.1038/mt.2008.61. Epub 2008 Mar 25. Mol Ther. 2008. PMID: 18388909
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- Ly H, Kawase Y, Yoneyama R, Hajjar RJ. Gene therapy in the treatment of heart failure. Physiology (Bethesda) 2007;22:81–96. - PubMed
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- del Monte F, Hajjar RJ, Harding SE. Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure. Circ Res. 2001;88:E66–E67. - PubMed
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- Lebeche D, Kaprelian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, et al. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004;110:3435–3443. - PubMed
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