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. 1991 May;65(5):2732-5.
doi: 10.1128/JVI.65.5.2732-2735.1991.

Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection

G Hirka  1 , K Prakash, H Kawashima, S A Plotkin, P W Andrews, E Gönczöl
Affiliations

Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection

G Hirka et al. J Virol. 1991 May.

Abstract

Human immunodeficiency virus (HIV) replicates in differentiated but not undifferentiated NTERA-2 human embryonal carcinoma cells; neither cell type expresses CD4. Susceptibility of the differentiated cells is enhanced by coinfection with cytomegalovirus. HIV infection induces lactoseries glycolipids, suggesting a mechanism whereby HIV might interfere with normal embryogenesis.

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