Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Oct 8;269(2):269-80.
doi: 10.1016/j.canlet.2008.04.014. Epub 2008 May 22.

Multitargeted therapy of cancer by green tea polyphenols

Naghma Khan  1 , Hasan Mukhtar
Affiliations
Review

Multitargeted therapy of cancer by green tea polyphenols

Naghma Khan et al. Cancer Lett. .

Abstract

Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others have been investigating the potential cancer preventive and therapeutic effects of green tea and its polyphenolic mixture termed GTP. It has become clear that much of these effects of GTP are mediated by its most abundant catechin, epigallocatechin gallate (EGCG). Large amount of encouraging data from in vitro and animal models has emerged making clear that green tea is a nature's gift molecule endowed with anticancer effects. Epidemiological and geographical observations suggest that these laboratory data may be applicable to human population. Clinical trials of GTP, especially in prostate cancer patients have yielded encouraging results. This article briefly reviews properties of GTP, especially EGCG with reference to multitargeted therapy of cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Chemical structures of major green tea polyphenols.
Figure 2
Figure 2
Effect of green tea polyphenol, EGCG on the modulation of various signal transduction pathways.
See this image and copyright information in PMC

References

    1. Mukhtar H, Ahmad N. Cancer chemoprevention: future holds in multiple agents. Toxicol. Appl. Pharmacol. 1999;158:207–210. - PubMed
    1. Khan N, Mukhtar H. Tea polyphenols for health promotion. Life Sci. 2007;81:519–533. - PMC - PubMed
    1. Khan WA, Wang ZY, Athar M, Bickers DR, Mukhtar H. Inhibition of the skin tumorigenicity of (+/−)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by tannic acid, green tea polyphenols and quercetin in Sencar mice. Cancer Lett. 1988;42:7–12. - PubMed
    1. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: Progress and Promise. Antioxid Redox Signal. 2007;10:475–510. - PubMed
    1. Lambert JD, Yang CS. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat. Res. 2003;523–524:201–208. - PubMed

Publication types

MeSH terms