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. 2008 Jun;57(6):845-52.
doi: 10.1016/j.metabol.2008.01.030.

Uric acid and the development of metabolic syndrome in women and men

Xuemei Sui  1 , Timothy S Church, Rebecca A Meriwether, Felipe Lobelo, Steven N Blair
Affiliations

Uric acid and the development of metabolic syndrome in women and men

Xuemei Sui et al. Metabolism. 2008 Jun.

Abstract

Associations between serum uric acid (UA) levels and metabolic syndrome (MetS) have been reported in cross-sectional studies. Limited information, however, is available concerning the prospective association of UA and the risk of developing MetS. The authors evaluated UA as a risk factor for incident MetS in a prospective study of 8429 men and 1260 women (aged 20-82 years) who were free of MetS and for whom measures of waist girth, resting blood pressure, fasting lipids, and glucose were taken during baseline and follow-up examinations between 1977 and 2003. Hyperuricemia was defined as >7.0 mg/dL in men and >6.0 mg/dL in women. Metabolic syndrome was defined with the National Cholesterol Education Program Adult Treatment Panel III criteria. The overall prevalence of hyperuricemia was 17%. During a mean follow-up of 5.7 years, 1120 men and 44 women developed MetS. Men with serum UA concentrations > or =6.5 mg/dL (upper third) had a 1.60-fold increase in risk of MetS (95% confidence interval, 1.34-1.91) as compared with those who had concentrations <5.5 mg/dL (lowest third). Among women, the risk of MetS was at least 2-fold higher for serum UA concentrations > or =4.6 mg/dL (P for trend = .02). Higher serum UA is a strong and independent predictor of incident MetS in men and women.

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Figures

Fig. 1
Fig. 1
Cumulative incidence of metabolic syndrome by thirds of uric acid in men and women, Aerobics Center Longitudinal Study, 1977–2003. The 95% confidence intervals are shown. White bars represent the lower third; striped bars, the middle third; and grey bars, the upper third of baseline serum uric acid. The number of cases is shown above the bars. Number at risk in lower, middle, and upper thirds of serum uric acid was 2,897, 2,827, and 2,705 in men and 418, 424, and 418 in women, respectively. *adjusted for age and examination year.
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