Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jun 19;10(12):2521-4.
doi: 10.1021/ol800802c. Epub 2008 May 27.

Catalytic atropo-enantioselective reduction of biaryl lactones to axially chiral biaryl compounds

Tomoko Ashizawa  1 , Saiko Tanaka, Tohru Yamada
Affiliations

Catalytic atropo-enantioselective reduction of biaryl lactones to axially chiral biaryl compounds

Tomoko Ashizawa et al. Org Lett. .

Abstract

The atropo-enantioselective borohydride reduction with dynamic kinetic resolution of biaryl lactones was catalyzed by an optically active beta-ketoiminatocobalt(II) complex to afford optically active biaryl compounds. Chiral HPLC analysis of the starting biaryl lactones was performed at various temperatures to determine suitable reaction conditions for dynamic kinetic resolution. Various types of axially chiral biaryl compounds were obtained with high enantioselectivity.

PubMed Disclaimer

LinkOut - more resources