Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 May 28;14(20):3224-30.
doi: 10.3748/wjg.14.3224.

Prognostic factors in patients with advanced cholangiocarcinoma: role of surgery, chemotherapy and body mass index

Mirna H Farhat  1 , Ali I Shamseddine, Ayman N Tawil, Ghina Berjawi, Charif Sidani, Wael Shamseddeen, Kassem A Barada
Affiliations

Prognostic factors in patients with advanced cholangiocarcinoma: role of surgery, chemotherapy and body mass index

Mirna H Farhat et al. World J Gastroenterol. .

Abstract

Aim: To study the factors that may affect survival of cholangiocarcinoma in Lebanon.

Methods: A retrospective review of the medical records of 55 patients diagnosed with cholangio-carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival.

Results: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05).

Conclusion: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A: Bilirubin level ≥ 10 mg/dL at presentation was associated with decreased survival as compared to lower levels; B: Chemotherapy administration prolonged survival in cholangiocarcinoma patients; C: Surgery added survival benefit in patients with cholangiocarcinoma.
See this image and copyright information in PMC

References

    1. Jarnagin WR, Fong Y, DeMatteo RP, Gonen M, Burke EC, Bodniewicz BS J, Youssef BA M, Klimstra D, Blumgart LH. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 2001;234:507–517; discussion 517-519. - PMC - PubMed
    1. Vauthey JN, Blumgart LH. Recent advances in the management of cholangiocarcinomas. Semin Liver Dis. 1994;14:109–114. - PubMed
    1. Jarnagin WR, Shoup M. Surgical management of cholangiocarcinoma. Semin Liver Dis. 2004;24:189–199. - PubMed
    1. Su CH, Tsay SH, Wu CC, Shyr YM, King KL, Lee CH, Lui WY, Liu TJ, P'eng FK. Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma. Ann Surg. 1996;223:384–394. - PMC - PubMed
    1. Patel T, Singh P. Cholangiocarcinoma: emerging approaches to a challenging cancer. Curr Opin Gastroenterol. 2007;23:317–323. - PubMed

MeSH terms