Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Mar;69(1):18-23.
doi: 10.4081/monaldi.2008.407.

Could IFN-gamma predict the development of residual pleural thickening in tuberculous pleurisy?

I Gerogianni  1 , M Papala, P Tsopa, P Zigoulis, A Dimoulis, K Kostikas, T Kiropoulos, K I Gourgoulianis
Affiliations

Could IFN-gamma predict the development of residual pleural thickening in tuberculous pleurisy?

I Gerogianni et al. Monaldi Arch Chest Dis. 2008 Mar.

Abstract

Background: The aim of our study was to identify predictive factors for the development of residual pleural thickening (RPT) in patients with tuberculous pleurisy (TP).

Methods: A retrospective study of patients with pleural tuberculosis. The clinical and radiological characteristics, and measurements of microbiological and biochemical parameters or markers such as adenosine deaminase (ADA), interferon-gamma (IFN-gamma) and vascular endothelial growth factor (VEGF) in pleural fluid were studied.

Results: Thirty one patients (24 male and 7 female) with a mean age of 55.9 years were studied. There were 25 (80.6%) patients with RPT > 2 mm and 6 (19.4%) patients without RPT. Ten patients (32.2%) had RPT > or = 10 mm. The rate of pleural thickening was less in small effusions (p<0.05). IFN-gamma was higher in patients with RPT > or = 10 mm (p < 0.05) in comparison with those with RPT < 10 mm.

Conclusions: Pleural fluid IFN-gamma may deserve further investigation in order to build up preventive and therapeutic strategies against RPT and its clinical complications.

PubMed Disclaimer

Comment in

  • Tuberculosis, one disease, many faces.
    Migliori GB, Centis R, Lange C, Matteelli A, Cirillo D. Migliori GB, et al. Monaldi Arch Chest Dis. 2008 Mar;69(1):2-4. doi: 10.4081/monaldi.2008.404. Monaldi Arch Chest Dis. 2008. PMID: 18507192 No abstract available.

Substances

LinkOut - more resources