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. 2008 May-Jun;37(3):262-73.
doi: 10.1111/j.1552-6909.2008.00238.x.

Predictors of wheezing in prematurely born children

Diane Holditch-Davis  1 , Piper Merrill, Todd Schwartz, Mark Scher
Affiliations

Predictors of wheezing in prematurely born children

Diane Holditch-Davis et al. J Obstet Gynecol Neonatal Nurs. 2008 May-Jun.

Abstract

Objective: To examine the degree to which neonatal illness severity, postneonatal health problems, child characteristics, parenting quality as measured by the HOME Inventory, and maternal characteristics are related to the development of wheezing in prematurely born children over the first 27 months after term.

Design: Longitudinal predictive study.

Setting: Infants were recruited from two neonatal intensive care units, one in southeast and one in Midwest.

Participants: One hundred thirteen preterm infants who weighed less than 1,500 g or required mechanical ventilation and their mothers.

Main outcome measures: The presence of wheezing was obtained from maternal report at 2, 6, 9, 13, 18, 22, and 27 months. Wheezing was considered to be medically significant if the child was using bronchodilators or pulmonary antiinflammatory medications.

Results: Sixty-eight percent of the children had wheezing at least one or more ages; 47% of the children were also taking bronchodilators or pulmonary antiinflammatory medications and thus had medically significant wheezing.

Conclusion: Postneonatal health problems and the social environment appear to be more important in developing wheezing in prematurely born children than neonatal medical complications.

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Figures

Figure 1
Figure 1
The model-predicted probabilities of a prematurely born children having medically significant and mild wheezing over age. The covariates are held constant at their means. The solid line shows the predicted probability for medically significant wheezing, the dotted line is mild wheezing, and the line with short and long dashes is no wheezing.
See this image and copyright information in PMC

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