Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jun;14(6):954-7.
doi: 10.3201/eid1406.071168.

Ceftriaxone-resistant salmonella enterica serotype Newport, France

Svetlana Egorova  1 , Mohammed Timinouni, Marie Demartin, Sophie A Granier, Jean M Whichard, Vartul Sangal, Laëtitia Fabre, Aurélia Delauné, Maria Pardos, Yves Millemann, Emmanuelle Espié, Mark Achtman, Patrick A D Grimont, François-Xavier Weill
Affiliations

Ceftriaxone-resistant salmonella enterica serotype Newport, France

Svetlana Egorova et al. Emerg Infect Dis. 2008 Jun.

Abstract

The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 beta-lactamase (Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during 2000-2005. Because this strain was not detected in food animals, it was most likely introduced into France through imported food products.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative XbaI pulsed-field gel electrophoresis (PFGE) profiles of third-generation cephalosporin–resistant Salmonella Newport isolates studied. A dendrogram was generated with Bionumerics software (Applied Maths, Sint-Martens-Latem, Belgium). The PFGE profile (and if there were indistinguishable isolates in the PulseNet USA database [www.cdc.gov/pulsenet], the corresponding Centers for Disease Control and Prevention PulseNet profile), the number of isolates, and the β-lactamase genes are indicated.
Figure 2
Figure 2
Representative PstI restriction profiles (A) and blaCMY-2 Southern hybridization (B) of plasmids from Escherichia coli DH10B transformants of CMY-2–producing Salmonella spp. clinical isolates. Lane M, Raoul molecular mass marker (Qbiogene, Illkirch, France). Lane 1, DH10B/00-7490; lane 2, DH10B/03-3349; lane 3, DH10B/03-3367; lane 4, DH10B/00-3525; lane 5, DH10B/00-4165; lane 6, DH10B/03-9969; lane 7, DH10B/03-9243; lane 8, DH10B/02-2049. Values on the left of panel A are in kb. Restriction and hybridization profiles are indicated. The gel is focused on the resolution of high molecular mass bands; smaller bands (in particular, the 0.8-kb band) are not well visualized.
See this image and copyright information in PMC

References

    1. Arlet G, Barrett TJ, Butaye P, Cloeckaert A, Mulvey MR, White DG. Salmonella resistant to extended-spectrum cephalosporins: prevalence and epidemiology. Microbes Infect. 2006;8:1945–54. 10.1016/j.micinf.2005.12.029 - DOI - PubMed
    1. Dunne EF, Fey PD, Kludt P, Reporter R, Mostashari F, Shillam P, et al. Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. JAMA. 2000;284:3151–6. 10.1001/jama.284.24.3151 - DOI - PubMed
    1. Rankin SC, Aceto H, Cassidy J, Holt J, Young S, Love B, et al. Molecular characterization of cephalosporin-resistant Salmonella enterica serotype Newport isolates from animals in Pennsylvania. J Clin Microbiol. 2002;40:4679–84. 10.1128/JCM.40.12.4679-4684.2002 - DOI - PMC - PubMed
    1. Zhao S, Qaiyumi S, Friedman S, Singh R, Foley SL, White DG, et al. Characterization of Salmonella enterica serotype Newport isolated from humans and food animals. J Clin Microbiol. 2003;41:5366–71. 10.1128/JCM.41.12.5366-5371.2003 - DOI - PMC - PubMed
    1. Whichard JM, Joyce K, Fey PD, Nelson JM, Angulo FJ, Barrett TJ. Beta-lactam resistance and Enterobacteriaceae, United States. Emerg Infect Dis. 2005;11:1464–6. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources