Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jun;14(6):966-7.
doi: 10.3201/eid1406.071266.

High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo

Affiliations

High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo

Jo Robays et al. Emerg Infect Dis. 2008 Jun.

Abstract

A retrospective chart review of 4,925 human African trypanosomiasis patients treated with melarsoprol in 2001-2003 in Equateur Nord Province of the Democratic Republic of Congo showed a treatment failure rate of 19.5%. This rate increased over the 3 years. Relapse rates were highest in the central part of the province.

PubMed Disclaimer

References

    1. Moore AC. Prospects for improving African trypanosomiasis chemotherapy. J Infect Dis. 2005;191:1793–5. 10.1086/429935 - DOI - PubMed
    1. Legros D, Fournier C, Gastellu EM, Maiso F, Szumilin E. Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda. Bull Soc Pathol Exot. 1999;92:171–2. - PubMed
    1. Matovu E, Enyaru JC, Legros D, Schmid C, Seebeck T, Kaminsky R. Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda. Trop Med Int Health. 2001;6:407–11. 10.1046/j.1365-3156.2001.00712.x - DOI - PubMed
    1. Stanghellini A, Josenando T. The situation of sleeping sickness in Angola: a calamity. Trop Med Int Health. 2001;6:330–4. 10.1046/j.1365-3156.2001.00724.x - DOI - PubMed
    1. Lutumba P, Robays J, Miaka mia Bilenge C, Mesu VK, Molisho D, Declercq J, et al. Trypanosomiasis control, Democratic Republic of Congo, 1993–2003. Emerg Infect Dis. 2005;11:1382–9. - PMC - PubMed

MeSH terms

LinkOut - more resources