doi: 10.1016/j.expneurol.2008.04.006.
Epub 2008 Apr 15.
Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease
Affiliations
- PMID: 18508049
- DOI: 10.1016/j.expneurol.2008.04.006
Item in Clipboard
Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease
Exp Neurol.
2008 Aug.
Abstract
Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has been proposed to counteract neuronal loss in animal models of neurodegeneration. To test this hypothesis, we investigated the effect of dietary restriction (DR) in a rodent model of Parkinson's disease, based on the intrastriatal infusion of 6-hydroxydopamine. We could not confirm the neuroprotective effect of DR previously suggested: histological and behavioral measures indicated similar degrees of dopaminergic neuron loss in rats maintained on DR--for two or eight weeks prior to the lesion--or with free access to food.
Similar articles
-
Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats.Neurosci Lett. 2007 Aug 9;423(1):12-7. doi: 10.1016/j.neulet.2007.06.031. Epub 2007 Jun 28. Neurosci Lett. 2007. PMID: 17644250
-
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.Neurosci Lett. 2009 Apr 3;453(2):81-5. doi: 10.1016/j.neulet.2009.02.016. Epub 2009 Feb 12. Neurosci Lett. 2009. PMID: 19356598
-
Effect of acupuncture on 6-hydroxydopamine-induced nigrostratal dopaminergic neuronal cell death in rats.Neurosci Lett. 2005 Aug 12-19;384(1-2):133-8. doi: 10.1016/j.neulet.2005.04.068. Neurosci Lett. 2005. PMID: 15893426
-
Controversies on new animal models of Parkinson's disease pro and con: the rotenone model of Parkinson's disease (PD).J Neural Transm Suppl. 2006;(70):273-6. J Neural Transm Suppl. 2006. PMID: 17017541 Review.
-
Restorative strategies for the dopaminergic nigrostriatal projection pathway.Acta Neurochir Suppl. 2013;117:79-85. doi: 10.1007/978-3-7091-1482-7_13. Acta Neurochir Suppl. 2013. PMID: 23652661 Review.
Cited by
-
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging.Front Physiol. 2021 Nov 25;12:715443. doi: 10.3389/fphys.2021.715443. eCollection 2021. Front Physiol. 2021. PMID: 34899367 Free PMC article. Review.
-
Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice.Front Cell Neurosci. 2018 Jan 17;12:4. doi: 10.3389/fncel.2018.00004. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29387000 Free PMC article.
-
Dietary factors in the etiology of Parkinson's disease.Biomed Res Int. 2015;2015:672838. doi: 10.1155/2015/672838. Epub 2015 Jan 20. Biomed Res Int. 2015. PMID: 25688361 Free PMC article. Review.
-
Initiation of calorie restriction in middle-aged male rats attenuates aging-related motoric decline and bradykinesia without increased striatal dopamine.Neurobiol Aging. 2016 Jan;37:192-207. doi: 10.1016/j.neurobiolaging.2015.10.006. Epub 2015 Oct 19. Neurobiol Aging. 2016. PMID: 26610387 Free PMC article.
-
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link.Int J Mol Sci. 2019 Jan 22;20(3):464. doi: 10.3390/ijms20030464. Int J Mol Sci. 2019. PMID: 30678217 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
