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Review
. 2008 Aug 6;94(5):670-4.
doi: 10.1016/j.physbeh.2008.04.018. Epub 2008 May 27.

CNS GLP-1 regulation of peripheral glucose homeostasis

Darleen Sandoval  1
Affiliations
Review

CNS GLP-1 regulation of peripheral glucose homeostasis

Darleen Sandoval. Physiol Behav. .

Abstract

Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis.

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Figures

Figure 1
Figure 1
Model for integration of peripheral and CNS GLP-1 systems in regulation of glucose homeostasis. a) After a meal, peripheral GLP-1 is secreted from the L-cells within the small intestine. b) GLP-1 binds to GLP-1r within within the hepatoportal region. c&d) This activates vagal afferent feedback to the nodose ganglia. e and f) this afferent feedback stimulates the GLP-1 neurons within the nucleus of the solitary tract (NTS) which projects to the arcuate nucleus of the hypothalamus. g) this leads to increased efferent activity to the pancreas, liver, and skeletal muscle and consequently an increase insulin secretion, and decrease glucose production and uptake, respectively. The overall effect of the peripheral and CNS GLP-1 system is to limit postprandial glycemic excursions.
See this image and copyright information in PMC

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