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. 1991 Apr 25;350(6320):678-83.
doi: 10.1038/350678a0.

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

B L Hempstead  1 , D Martin-Zanca, D R Kaplan, L F Parada, M V Chao
Affiliations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

B L Hempstead et al. Nature. .

Abstract

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.

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