doi: 10.1038/350678a0.
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
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- PMID: 1850821
- DOI: 10.1038/350678a0
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High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
Nature.
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Abstract
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.
Comment in
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Neurobiology. trking neurotrophic receptors.Nature. 1991 Apr 25;350(6320):660-1. doi: 10.1038/350660a0. Nature. 1991. PMID: 1850820 No abstract available.
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