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. 2008 Jul;64(1):53-9.
doi: 10.1002/ana.21403.

Ambient air pollution and risk for ischemic stroke and transient ischemic attack

Lynda D Lisabeth  1 , James D Escobar, J Timothy Dvonch, Brisa N Sánchez, Jennifer J Majersik, Devin L Brown, Melinda A Smith, Lewis B Morgenstern
Affiliations

Ambient air pollution and risk for ischemic stroke and transient ischemic attack

Lynda D Lisabeth et al. Ann Neurol. 2008 Jul.

Abstract

Objective: Data on the association between air pollution and cerebrovascular disease in the United States are limited. The objective of this study was to investigate the association between short-term exposure to ambient air pollution and risk for ischemic cerebrovascular events in a US community.

Methods: Daily counts of ischemic strokes/transient ischemic attacks (TIAs) (2001-2005) were obtained from the population-based Brain Attack Surveillance in Corpus Christi (BASIC) Project. Daily particulate matter less than 2.5microm in diameter (PM(2.5)), ozone (O(3)), and meteorological data were obtained from Texas Commission on Environmental Quality. To examine the association between PM(2.5) and stroke/TIA risk, we used Poisson regression. Separate models included same-day PM(2.5), PM(2.5) lagged 1 to 5 days, and an averaged lag effect. All models were adjusted for temperature, day of week, and temporal trends in stroke/TIA. The effects of O(3) were also investigated.

Results: Median PM(2.5) was 7.0microg/m(3) (interquartile range, 4.8-10.0microg/m(3)). There were borderline significant associations between same-day (relative risk [RR], 1.03; 95% confidence interval [CI], 0.99-1.07 for an interquartile range increase in PM(2.5)) and previous-day (RR, 1.03; 95% CI, 1.00-1.07) PM(2.5) and stroke/TIA risk. These associations were independent of O(3), which demonstrated similar associations with stroke/TIA risk (same-day RR, 1.02; 95% CI, 0.97-1.08; previous-day RR, 1.04; 95% CI, 0.99-1.09).

Interpretation: We observed associations between recent PM(2.5) and O(3) exposure and ischemic stroke/TIA risk even in this community with relatively low pollutant levels. This study provides data on environmental exposures and stroke risk in the United States, and suggests future research on ambient air pollution and stroke is warranted.

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Figures

Figure 1
Figure 1
Air pollutant point emission sources in Nueces County, Texas.
Figure 2
Figure 2
Daily and median level of PM2.5 over the study time period (2001–2005) with median PM2.5 levels for two referent US cities.
Figure 3
Figure 3
Percent change in stroke/TIA risk associated with an IQR (5.1 μg/m3) increase in PM2.5.
See this image and copyright information in PMC

References

    1. Kunzli N, Jerrett M, Mack WJ, et al. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect. 2005;113:201–206. - PMC - PubMed
    1. Moolgavkar SH. Air pollution and daily mortality in three U.S. counties. Environ Health Perspect. 2000;108:777–784. - PMC - PubMed
    1. Moolgavkar SH. Air pollution and hospital admissions for diseases of the circulatory system in three U.S. metropolitan areas. Journal of the Air & Waste Management Association (1995) 2000;50:1199–1206. - PubMed
    1. Samet JM, Dominici F, Curriero FC, et al. Fine particulate air pollution and mortality in 20 U.S. cities, 1987–1994. N Engl J Med. 2000;343:1742–1749. - PubMed
    1. Schwartz J. Air pollution and hospital admissions for cardiovascular disease in Tucson. Epidemiology. 1997;8:371–377. - PubMed

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