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Review
. 2008 May 1:13:4925-32.
doi: 10.2741/3051.

Protein tyrosine phosphatases in the JAK/STAT pathway

Dan Xu  1 , Cheng-Kui Qu
Affiliations
Review

Protein tyrosine phosphatases in the JAK/STAT pathway

Dan Xu et al. Front Biosci. .

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.

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References

    1. Darnell JE, Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;26:1415–1421. - PubMed
    1. Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 2003;3:900–911. - PubMed
    1. Qu CK. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim Biophys Acta. 2002;159:297–301. - PubMed
    1. Tonks NK, Neel BG. Combinatorial control of the specificity of protein tyrosine phosphatases. Curr Opin Cell Biol. 2001;13:182–195. - PubMed
    1. Darnell JE., Jr STATs and gene regulation. Science. 1997;277:1630–1635. - PubMed

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