Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Jun 3;105(22):7627-8.
doi: 10.1073/pnas.0803901105. Epub 2008 May 28.

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction

Edward W Kraegen  1 , Gregory J Cooney, Nigel Turner
Affiliations
Comment

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction

Edward W Kraegen et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Interrelationship of energy metabolism and insulin action in skeletal muscle. Fatty acids and glucose are both substrates for energy metabolism in skeletal muscle. Cytosolic accumulation of lipid species such as diacylglycerol and ceramide are thought to decrease insulin action by inhibiting the insulin signaling pathway (blue shaded box). Metabolism of fatty acids by muscle cells is subject to regulation at the level of uptake and activation of fatty acids, the entry of activated fatty acids into the mitochondrion (CPT-1) and the capacity of the β-oxidation pathway, the tricarboxylic acid (TCA) cycle, electron transport chain (complex I–IV), and ATP synthesis (complex V) (red boxes). The balance between uptake and utilization of fatty acids will ultimately determine the magnitude of lipid accumulation in muscle cells.
See this image and copyright information in PMC

Comment on

References

    1. Holland WL, et al. Lipid mediators of insulin resistance. Nutr Rev. 2007;65:S39–S46. - PubMed
    1. Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res. 2008;102:401–414. - PMC - PubMed
    1. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307:384–387. - PubMed
    1. Hancock CR, et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci USA. 2008;105:7815–7820. - PMC - PubMed
    1. Turner N, et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes. 2007;56:2085–2092. - PubMed