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Case Reports
. 2008:2008:825093.
doi: 10.1155/2008/825093.

Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma

Ofer Merimsky  1 , Irina Jiveliouk, Ronit Sagi-Eisenberg
Affiliations
Case Reports

Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma

Ofer Merimsky et al. Sarcoma. 2008.

Abstract

A 66-year old female with HIV-negative classic Kaposi's sarcoma responded to mTOR targeting by rapamycin. The response was well documented by PET-CT. This case provides supporting evidence that the mTOR pathway may be important in the tumorigenesis of KS and that rapamycin may have activity in this disease.

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Figures

Figure 1
Figure 1
PET-CT at initiation and at completion of almost 4-month rapamycin therapy.
See this image and copyright information in PMC

References

    1. Brash DB, Bale AE. Molecular biology of skin cancer. In: DeVita VT Jr., Hellman S, Rosenberg S, editors. Cancer Principles and Practice of Oncology. Philadelphia, Pa, USA: Lippincott Williams & Wilkins; 2000. pp. 1971–1975. chapter 41.
    1. McCaffrey P. Sirolimus does double duty after organ transplantation. The Lancet Oncology. 2005;6(5):page 261. - PubMed
    1. Mohsin N, Budruddin M, Pakkyara A, et al. Complete regression of visceral Kaposi’s sarcoma after conversion to sirolimus. Experimental and Clinical Transplantation. 2005;3(2):366–369. - PubMed
    1. Vasanawala MS, Wang Y, Quon A, Gambhir SS. F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp. Clinical Nuclear Medicine. 2006;31(9):534–537. - PubMed
    1. Dupont P, Warrens AN. The evolving role of sirolimus in renal transplantation. QJM. 2003;96(6):401–409. - PubMed

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