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Comment
. 2008 May 30;133(5):765-7.
doi: 10.1016/j.cell.2008.05.012.

Follow the monomer

James E Bear  1
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Free article
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Follow the monomer

James E Bear. Cell. .
Free article

Abstract

Capping proteins limit actin filament growth, but paradoxically increase actin-based cell motility. This has been attributed to funneling of actin monomers to the filament ends that remain uncapped. Using a reconstituted motility system, Akin and Mullins (2008) now demonstrate that filament capping increases Arp2/3-based nucleation and branching, rather than elevating the rate of filament elongation.

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