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Review
. 2008 May 30;133(5):775-87.
doi: 10.1016/j.cell.2008.05.009.

Regulatory T cells and immune tolerance

Shimon Sakaguchi  1 , Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono
Affiliations
Free article
Review

Regulatory T cells and immune tolerance

Shimon Sakaguchi et al. Cell. .
Free article

Abstract

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

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