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. 2008 May;63(5):447-53.
doi: 10.1093/gerona/63.5.447.

Adiponectin levels and genotype: a potential regulator of life span in humans

Gil Atzmon  1 , Toni I Pollin, Jill Crandall, Keith Tanner, Clyde B Schechter, Philipp E Scherer, Marielisa Rincon, Glenn Siegel, Micol Katz, Richard B Lipton, Alan R Shuldiner, Nir Barzilai
Affiliations

Adiponectin levels and genotype: a potential regulator of life span in humans

Gil Atzmon et al. J Gerontol A Biol Sci Med Sci. 2008 May.

Abstract

Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p =.01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p =.02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.

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Figures

Figure 1
Figure 1
Adiponectin levels according to age. a, Adiponectin levels, adjusted for sex and body mass index (BMI) in long-lived probands and controls. This group represents a continuous age group of unrelated individuals from 51 to 106 years of age. b, Adiponectin levels, adjusted for BMI in long-lived probands and controls stratified by sex. c, Adiponectin levels, adjusted for BMI in offspring of long-lived probands stratified by sex. *p = .05, **p = .01 for comparison to the <65-year-old group. #p < .05 for comparison to the 66- to 75-year-old group. ‡p < .05 for comparison to the 76- to 85-year-old group. §p < .01 for comparison to females within stratified group.
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