Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;135(2):297-301.
doi: 10.1007/s00432-008-0424-0. Epub 2008 May 30.

Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation

Min Soo Kim  1 , Eun Hee Kook, Se Han Ahn, Se Young Jeon, Jung Ho Yoon, Min Sung Han, Cheol Hyeon Kim, Jae Cheol Lee
Affiliations

Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation

Min Soo Kim et al. J Cancer Res Clin Oncol. 2009 Feb.

Abstract

Purpose: The aim of this study was to report the clinical characteristics and outcomes of gastrointestinal metastasis from lung cancer, with special emphasis on a long-term survivor after surgery.

Methods: We retrospectively reviewed all patients diagnosed with lung cancer between 2000 and 2007 at a tertiary referral center for cancer.

Results: Gastrointestinal metastases were detected in 10 (0.19%) of 5,239 lung cancer patients. Small bowel metastases occurred in one-half of the patients, making it the most common metastatic site. One patient underwent emergency surgery because of an intestinal perforation. Although a perforation developed only in this patient, surgical intervention was required for five other patients to relieve intestinal obstruction or control bleeding. The prognosis was poor, with a median survival of 96.5 days after diagnosis. However, one patient remains alive >5 years post-operatively, without a recurrence, suggesting that surgical resection is an option for cure in properly selected patients.

Conclusions: Physicians should be familiar with unique features of lung cancer with metastasis to the gastrointestinal tract so as to render early and optimal management.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Pathologic examination of lung tumor (a) showed nested adenocarcinomatous area (right lower) and highly pleomorphic sarcomatous cells with inflammatory cell infiltration (left upper), which were similar to that of jejunal tumor (b) (H&E, ×200). Immunohistochemical stainings were also almost identical in both tumors of lung and jejunum showing CK7+ (c)/CK20− (d) in carcinoma cells and vimentin+ (e) in sarcomatous cells
See this image and copyright information in PMC

References

    1. Antler AS, Ough Y, Pitchumoni CS, Davidian M, Thelmo W (1982) Gastrointestinal metastases from malignant tumors of the lung. Cancer 49(1):170–172. doi:10.1002/1097-0142(19820101)49:1<170::AID-CNCR2820490134>3.0.CO;2-A - PubMed
    1. Berger A, Cellier C, Daniel C, Kron C, Riquet M, Barbier JP et al (1999) Small bowel metastases from primary carcinoma of the lung: clinical findings and outcome. Am J Gastroenterol 94(7):1884–1887. doi:10.1111/j.1572-0241.1999.01224.x - PubMed
    1. Burbige EJ, Radigan JJ, Belber JP (1980) Metastatic lung carcinoma involving the gastrointestinal tract. Am J Gastroenterol 74(6):504–506 - PubMed
    1. Chee RJ, Bydder S, Cameron F (2007) Prolonged survival after resection and radiotherapy for solitary brain metastases from non-small-cell lung cancer. Australas Radiol 51(2):186–189. doi:10.1111/j.1440-1673.2007.01702.x - PubMed
    1. Gamez C, Rosell R, Fernandez A, Andia E, Arnaiz MD, Cardenal F et al (2006) PET/CT fusion scan in lung cancer: current recommendations and innovations. J Thorac Oncol 1(1):74–77 - PubMed

MeSH terms